The Binding Selectivity of ADAR2's dsRBMs Contributes to RNA-Editing Selectivity
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A Unique RNA Fold in the RumA-RNA-Cofactor Ternary Complex Contributes to Substrate Selectivity and Enzymatic Function
A single base (U1939) within E. coli 23S ribosomal RNA is methylated by its dedicated enzyme, RumA. The structure of RumA/RNA/S-adenosylhomocysteine uncovers the mechanism for achieving unique selectivity. The single-stranded substrate is "refolded" on the enzyme into a compact conformation with six key intra-RNA interactions. The RNA substrate contributes directly to catalysis. In addition to ...
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To whom the correspondence should be addressed: Gunnar Schulte, Section of Receptor Biology & Signaling, Dept. Physiology & Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden. Tel.: +46-8-52487933; Fax: +46-8-341280; E-mail: [email protected] Rami N. Hannoush, Department of Early Discovery Biochemistry, Genentech, 1 DNA Way, South San Francisco, California 94080, United States. ...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2004
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2004.06.009